White House overhauls rules for risky pathogen studies
The White House is tightening federal oversight of so-called gain-of-function (GOF) studies that could enhance risky viruses in ways that increase their ability to cause a pandemic. It is also overhauling rules for a broader category of federally funded research on dangerous pathogens that is considered “dual use,” because the results could be used as bioweapons.
The new rules, spurred by the COVID-19 pandemic and concerns about U.S.-funded studies in Wuhan, China, that manipulated bat viruses distantly related to SARS-CoV-2, will expand the number of studies that must undergo special reviews. But the rules,
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Source: Science of Aging Knowledge Environment - May 7, 2024 Category: Geriatrics Source Type: research
Monkeypox: A risk factor for inflammatory diseases?
Eur J Intern Med. 2024 May 3:S0953-6205(24)00183-3. doi: 10.1016/j.ejim.2024.04.022. Online ahead of print.NO ABSTRACTPMID:38704292 | DOI:10.1016/j.ejim.2024.04.022 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 4, 2024 Category: Internal Medicine Authors: Giuseppe Famularo Source Type: research
Monkeypox: A risk factor for inflammatory diseases?
Eur J Intern Med. 2024 May 3:S0953-6205(24)00183-3. doi: 10.1016/j.ejim.2024.04.022. Online ahead of print.NO ABSTRACTPMID:38704292 | DOI:10.1016/j.ejim.2024.04.022 (Source: European Journal of Internal Medicine)
Source: European Journal of Internal Medicine - May 4, 2024 Category: Internal Medicine Authors: Giuseppe Famularo Source Type: research
Ocular manifestations of Monkeypox virus (MPXV) infection with viral persistence in ocular samples – a case series.
Mpox is a zoonotic disease caused by the Monkeypox virus (MPXV) [1]. Ophthalmologic involvement, termed Monkeypox virus-related ophthalmic disease (MPXROD), encompasses a range of eye-related manifestations that can occur during Monkeypox virus (MPXV) infection. This includes lesions affecting both external structures, such as the periorbita and eyelids, as well as the ocular surface, including conditions like blepharoconjunctivitis, ulcerative keratitis, immune stromal and neurotrophic keratitis [2]. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - May 3, 2024 Category: Infectious Diseases Authors: Luciana P.S. Finamor, Maria C ássia Mendes-Correa, Mônica Rinkevicius, Guilherme Macedo, Ester Cerdeira Sabino, Lucy Santos Villas-Boas, Anderson Vicente de Paula, Raissa Heloisa de Araujo-Heliodoro, Antonio Charlys da Costa, Steven S. Witkin, Keila Lim Source Type: research
Anogeissus leiocarpus (DC.) Guill. & amp; Perr. (Combretaceae): A review of the traditional uses, phytochemistry and pharmacology of African birch
Fitoterapia. 2024 Apr 29:105979. doi: 10.1016/j.fitote.2024.105979. Online ahead of print.ABSTRACTAnogeissus leiocarpus (DC.) Guill. & Perr. belongs to the family Combretaceae and is used both by African traditional medical practitioners and livestock rearers to treat diseases such as African trypanosomiasis, animal diarrhoea, asthma, cancer, cough, diabetes, dysentery, erectile dysfunction, fever, giardiasis, helminthiases, meningitis, menstrual disorders, monkeypox, oral infections, poliomyelitis, sickle cell anaemia, snake bites, toothache, urinary schistosomiasis, and yellow fever. Some of these activities have bee...
Source: Fitoterapia - May 1, 2024 Category: Biochemistry Authors: Yemi A Adekunle Babatunde B Samuel Lutfun Nahar Amos A Fatokun Satyajit D Sarker Source Type: research
Machine learning in epidemiology: Neural networks forecasting of monkeypox cases
This study integrates advanced machine learning techniques, namely Artificial Neural Networks, Long Short-Term Memory, and Gated Recurrent Unit models, to forecast monkeypox outbreaks in Canada, Spain, the USA, and Portugal. The research focuses on the effectiveness of these models in predicting t he spread and severity of cases using data from June 3 to December 31, 2022, and evaluates them against test data from January 1 to February 7, 2023. The study highlights the potential of neural networks in epidemiology, especially concerning recent monkeypox outbreaks. It provides a comparative ana lysis of the models, emphasizi...
Source: PLoS One - May 1, 2024 Category: Biomedical Science Authors: Lulah Alnaji Source Type: research
Development of a CRISPR/Cas12a-mediated aptasensor for Mpox virus antigen detection
Biosens Bioelectron. 2024 Apr 24;257:116313. doi: 10.1016/j.bios.2024.116313. Online ahead of print.ABSTRACTThe emergence and rapid spread of Mpox (formerly monkeypox) have caused significant societal challenges. Adequate and appropriate diagnostics procedures are an urgent necessity. Herein, we discover a pair of aptamers through the systematic evolution of ligands by exponential enrichment (SELEX) that exhibit high affinity and bind to different sites towards the A29 protein of the Mpox virus. Subsequently, we propose a facile, sensitive, convenient CRISPR/Cas12a-mediated aptasensor for detecting the A29 antigen. The pro...
Source: Biosensors and Bioelectronics - April 30, 2024 Category: Biotechnology Authors: Cong Han Qirui Liu Xuantong Luo Jian Zhao Zheng Zhang Jiaxuan He Feng Ge Wei Ding Zhaofeng Luo Chao Jia Liyun Zhang Source Type: research
Development of a CRISPR/Cas12a-mediated aptasensor for Mpox virus antigen detection
Biosens Bioelectron. 2024 Apr 24;257:116313. doi: 10.1016/j.bios.2024.116313. Online ahead of print.ABSTRACTThe emergence and rapid spread of Mpox (formerly monkeypox) have caused significant societal challenges. Adequate and appropriate diagnostics procedures are an urgent necessity. Herein, we discover a pair of aptamers through the systematic evolution of ligands by exponential enrichment (SELEX) that exhibit high affinity and bind to different sites towards the A29 protein of the Mpox virus. Subsequently, we propose a facile, sensitive, convenient CRISPR/Cas12a-mediated aptasensor for detecting the A29 antigen. The pro...
Source: Biosensors and Bioelectronics - April 30, 2024 Category: Biotechnology Authors: Cong Han Qirui Liu Xuantong Luo Jian Zhao Zheng Zhang Jiaxuan He Feng Ge Wei Ding Zhaofeng Luo Chao Jia Liyun Zhang Source Type: research
Classical molecular dynamics simulation identifies catechingallate as a promising antiviral polyphenol against MPOX palmitoylated surface protein
Comput Biol Chem. 2024 Apr 12;110:108070. doi: 10.1016/j.compbiolchem.2024.108070. Online ahead of print.ABSTRACTCumulative global prevalence of the emergent monkeypox (MPX) infection in the non-endemic countries has been professed as a global public health predicament. Lack of effective MPX-specific treatments sets the baseline for designing the current study. This research work uncovers the effective use of known antiviral polyphenols against MPX viral infection, and recognises their mode of interaction with the target F13 protein, that plays crucial role in formation of enveloped virions. Herein, we have employed state-...
Source: Computational Biology and Chemistry - April 28, 2024 Category: Bioinformatics Authors: Sarbani Mishra Madhusmita Rout Mahender Kumar Singh Budheswar Dehury Sanghamitra Pati Source Type: research
Classical molecular dynamics simulation identifies catechingallate as a promising antiviral polyphenol against MPOX palmitoylated surface protein
Comput Biol Chem. 2024 Apr 12;110:108070. doi: 10.1016/j.compbiolchem.2024.108070. Online ahead of print.ABSTRACTCumulative global prevalence of the emergent monkeypox (MPX) infection in the non-endemic countries has been professed as a global public health predicament. Lack of effective MPX-specific treatments sets the baseline for designing the current study. This research work uncovers the effective use of known antiviral polyphenols against MPX viral infection, and recognises their mode of interaction with the target F13 protein, that plays crucial role in formation of enveloped virions. Herein, we have employed state-...
Source: Computational Biology and Chemistry - April 28, 2024 Category: Bioinformatics Authors: Sarbani Mishra Madhusmita Rout Mahender Kumar Singh Budheswar Dehury Sanghamitra Pati Source Type: research
Viruses, Vol. 16, Pages 681: Monkeypox Virus Neutralizing Antibodies at Six Months from Mpox Infection: Virologic Factors Associated with Poor Immunologic Response
This study found that the overall days of monkeypox virus detection in the body, irrespective of the viral loads, were directly correlated with monkeypox virus neutralizing antibodies at six months after infection. (Source: Viruses)
Source: Viruses - April 26, 2024 Category: Virology Authors: Angelo Roberto Raccagni Alessandro Mancon Sara Diotallevi Riccardo Lolatto Elena Bruzzesi Maria Rita Gismondo Antonella Castagna Davide Mileto Silvia Nozza Tags: Article Source Type: research
Infectious Disease Preparedness for Homeless Populations: Recommendations from a Community-Academic Partnership
CONCLUSIONS: Community-academic partnerships are critical to effective infectious disease preparedness in homeless populations. The lessons learned from community-based participatory research with homeless communities and multisectoral partners on the frontline can improve future outbreak and pandemic response for people experiencing homelessness and other vulnerable communities in the United States.PMID:38661832 (Source: Progress in Community Health Partnerships)
Source: Progress in Community Health Partnerships - April 25, 2024 Category: International Medicine & Public Health Authors: Natalia M Rodriguez Rebecca Ziolkowski Jodie Hicks Michelle Dearing Jennifer Layton Amanda Balser Grace Paton Gregory Loomis Source Type: research
